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KMID : 0895820110210040157
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Journal of Oriental Rehabilitation Medicine
2011 Volume.21 No. 4 p.157 ~ p.165
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Association of GNB3 Polymorphism with Obesity Index, Blood Pressure, Glucose and Lipid Level
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Kwon Dong-Hyun
Park Jung-Hyun
Lee Myeong-Jong
Song Mi-Young
Kim Ho-Jun
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Abstract
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Objectives: The aim of this study is to establish the association of GNB3 with obesity-index, blood pressure, glucose and lipid level.
Methods: A total of 209 Korean obese subjects participated in the study. Body weight, body mass index(BMI), waist circumference, body fat, body fat mass, resting metabolic rate, blood pressure, total cholesterol, high density lipoprotein, triglyceride and fasting blood sugar test were measured by using standardized protocols. The GNB3 was genotyped by using polymerase chain reaction with restriction fragment length polymorphism.
Results: The frequency of CC, CT, TT genotype were, respectively, 18.2%, 56.9%, 24.9%, and the frequency of T allele was 53.3% in Korean obese population. There were no association of GNB3 with obesity index, blood pressure, glucose and lipid level in Korean obese population.
Conclusions: Obese Korea population have a higher frequency of T alle than general Korean population. Threre are no association of GNB3 with obesity index, blood pressure, glucose and lipid level in Korean obese population.
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KEYWORD
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GNB3 polymorphism, Obesity, Hypertension
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